Early Puberty and Brain Development: Exploring the Neurobiology of Adolescent Mental Health.

Investigating Associations Between Maternal Behavior and the Development of Functional Connectivity During the Transition From Late Childhood to Early Adolescence

E Pozzi, D Rakesh, Z Gracia-Tabuenca, KO Bray, S Richmond, ML Seal, O Schwartz, N Vijayakumar, MBH Yap, S Whittle

2024-04-01

Background: Parenting behavior is thought to affect child brain development, with implications for mental health. However, longitu..

Estradiol variability is associated with brain structure in early adolescent females

IS Zwaan, K Felmingham, N Vijayakumar, G Patton, L Mundy, ML Byrne, J Simmons, S Whittle

2022-12-01

One-third of adolescents are diagnosed with a psychiatric disorder by age 16, with female adolescents twice as likely to experienc..

Harsh and Inconsistent Parental Discipline Is Associated With Altered Cortical Development in Children

S Whittle, E Pozzi, D Rakesh, JM Kim, MBH Yap, OS Schwartz, G Youssef, NB Allen, N Vijayakumar

2022-10-01

Background: A growing body of evidence suggests that parenting behaviors may affect child mental health via altering brain develop..

The development of structural covariance networks during the transition from childhood to adolescence

N Vijayakumar, G Ball, ML Seal, L Mundy, S Whittle, T Silk

2021-12-01

Structural covariance conceptualizes how morphologic properties of brain regions are related to one another (across individuals). ..

The effects of puberty and its hormones on subcortical brain development

N Vijayakumar, G Youssef, NB Allen, V Anderson, D Efron, L Mundy, G Patton, JG Simmons, T Silk, S Whittle

2021-08-01

Puberty triggers a period of structural “re-organization” in the brain, when rising hormone levels act via receptors to influence ..

A longitudinal analysis of puberty-related cortical development

N Vijayakumar, GJ Youssef, NB Allen, V Anderson, D Efron, P Hazell, L Mundy, JM Nicholson, G Patton, ML Seal, JG Simmons, S Whittle, T Silk

2021-03-01

The brain undergoes extensive structural changes during adolescence, concurrent to puberty-related physical and hormonal changes. ..

Adrenarcheal Timing Longitudinally Predicts Anxiety Symptoms via Amygdala Connectivity During Emotion Processing

MEA Barendse, JG Simmons, G Patton, L Mundy, ML Byrne, ML Seal, NB Allen, S Whittle

2020-06-01

Objective: This study aimed to examine longitudinally whether adrenarcheal timing (adrenarcheal hormone levels independent of age)..

Pubertal hormones predict sex-specific trajectories of pituitary gland volume during the transition from childhood to adolescence

S Whittle, M Barendse, E Pozzi, N Vijayakumar, JG Simmons

2020-01-01

Pituitary gland volume (PGV) increases during childhood and adolescence in a sex-specific manner, and previous research suggests t..

Relationships between adrenarcheal hormones, hippocampal volumes and depressive symptoms in children

R Ellis, A Fernandes, JG Simmons, L Mundy, G Patton, NB Allen, S Whittle

2019-06-01

Early timing of puberty (i.e., advanced pubertal maturation relative to same-age peers) has been associated with depressive sympto..

Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children

MEA Barendse, JG Simmons, ML Byrne, G Patton, L Mundy, CA Olsson, ML Seal, NB Allen, S Whittle

2018-11-01

Objective: The transition from childhood to adolescence is a vulnerable period for the development of anxiety symptoms. There is s..

Interaction Between Parenting Styles and Adrenarcheal Timing Associated With Affective Brain Function in Late Childhood

C Barbosa, JG Simmons, N Vijayakumar, P Dudgeon, GC Patton, LK Mundy, NB Allen, S Whittle

2018-09-01

Objective: Parenting and pubertal timing have consistently been associated with internalizing and externalizing symptoms in childh..

Brain structural connectivity during adrenarche: Associations between hormone levels and white matter microstructure

MEA Barendse, JG Simmons, ML Byrne, ML Seal, G Patton, L Mundy, SJ Wood, CA Olsson, NB Allen, S Whittle

2018-02-01

Levels of the adrenal hormones dehydroepiandrosterone (DHEA), its sulfate (DHEAS), and testosterone, have all been linked to behav..

Perinatal maternal alcohol consumption and methylation of the dopamine receptor DRD4 in the offspring: The Triple B study

PD Fransquet, D Hutchinson, CA Olsson, J Wilson, S Allsop, J Najman, E Elliott, RP Mattick, R Saffery, J Ryan

2016-12-01

Maternal alcohol use during the perinatal period is a major public health issue, the higher ends of which are associated with foet..

Associations between dehydroepiandrosterone (DHEA) levels, pituitary volume, and social anxiety in children

CR Murray, JG Simmons, NB Allen, ML Byrne, LK Mundy, ML Seal, GC Patton, CA Olsson, S Whittle

2016-02-01

Early timing of adrenarche, associated with relatively high levels of dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S) in c..

Depression, immune function, and early adrenarche in children

FM Delany, ML Byrne, S Whittle, JG Simmons, C Olsson, LK Mundy, GC Patton, NB Allen

2016-01-01

Despite consistent findings of an association between depression and immunity in adult and adolescent populations, little is known..

The lifetime experience of traumatic events is associated with hair cortisol concentrations in community-based children

JG Simmons, PB Badcock, SL Whittle, ML Byrne, L Mundy, GC Patton, CA Olsson, NB Allen

2016-01-01

Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal axis (HPAA) and increase risk for negati..

Reduced frontal white matter volume in children with early onset of adrenarche

P Klauser, S Whittle, JG Simmons, ML Byrne, LK Mundy, GC Patton, A Fornito, NB Allen

2015-01-01

While there is growing evidence that puberty affects brain development, very little is known about the structural brain changes as..

Associations between early adrenarche, affective brain function and mental health in children

S Whittle, JG Simmons, ML Byrne, C Strikwerda-Brown, R Kerestes, ML Seal, CA Olsson, P Dudgeon, LK Mundy, GC Patton, NB Allen

2014-10-21

Early timing of adrenarche, associated with relatively high levels of Dehydroepiandrosterone (DHEA) in children, has been associat..

Study protocol: Imaging brain development in the Childhood to Adolescence Transition Study (iCATS)

JG Simmons, SL Whittle, GC Patton, P Dudgeon, C Olsson, ML Byrne, LK Mundy, ML Seal, NB Allen

2014-04-30

Background: Puberty is a critical developmental phase in physical, reproductive and socio-emotional maturation that is associated ..